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Mitragynine and hydroxy-mitragynine (MHRB) is a intriguing plant native to Southeast Asia. Traditionally, it has been used for its analgesic properties and its role in spiritual ceremonies. Modern research is beginning the vast potential of MHRB, revealing significant applications covering a range of physical well-being aspects. This comprehensive guide delves into the complex world of MHRB, examining its history, active compounds, potential benefits, and related considerations.